反応 #338670

反応方程式

isopropylalcohol

sodium hydroxide

compound 9

2-Ethoxycarbonyl-1-methyl-4-{4-(1-methylimidazole-2-carboxamido)-1-methypyrrole-2-carboxamido}imidazole

hydrochloric acid

→

compound 10

収率 96.6%

Sodium 1-methyl-4-{4-(1-methylimidazole-2-carboxamido)-1-methypyrrole-2-carboxamido}imidazole-2-carboxylate

収率 96.6%

溶媒

methanol

反応条件

後処理

1. 1
   温度After being cooled to a room temperature
2. 2
   その他to give the white powder, which
3. 3
   ろ過was then filtered

実験手順

The compound 9 (3.0 g, 7.5 mmol) was dissolved in methanol (37.6 ml), mixed with aqueous solution of sodium hydroxide (37.6 ml, 7.89 mmol) and stirred for one hour at 50° C. After being cooled to a room temperature, the resulting solution was mixed with hydrochloric acid (1N) to reach pH 2.0, and then mixed with isopropylalcohol to give the white powder, which was then filtered to give the compound 10 (2.85 g, 94%).

出典