反応 #338285

ord-4d9cf3d9d0274f608165a9964a915e58

反応方程式

CC(=O)CCCN1C(=O)c2ccccc2C1=O
2-(4-oxo-pentyl)-isoindole-1,3-dione
CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
NaBH(OAc)3
CC(N)c1ccccn1
1-pyridin-2-yl-ethylamine
→
CC(CCCN1C(=O)c2ccccc2C1=O)NC(C)c1ccccn1
2-[4-(1-pyridin-2-yl-ethylamino)-pentyl]-isoindole-1,3-dione

反応物

CC(=O)CCCN1C(=O)c2ccccc2C1=O
2-(4-oxo-pentyl)-isoindole-1,3-dione
CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
NaBH(OAc)3
CC(N)c1ccccn1
1-pyridin-2-yl-ethylamine

試薬

なし

溶媒

ClCCl
CH2Cl2

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Using General Procedure B: Reaction of 2-(4-oxo-pentyl)-isoindole-1,3-dione (Abdel-Monem, M M et al. J. Med. Chem. 1974, 17, 447-451) in CH2Cl2 and 1-pyridin-2-yl-ethylamine with NaBH(OAc)3 gave 2-[4-(1-pyridin-2-yl-ethylamino)-pentyl]-isoindole-1,3-dione as a colorless oil.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07863293B2uspto-grants-2011_01