反応 #338025

反応方程式

(3-benzyloxy-4-iodophenyl)methanol

→

3-benzyloxy-4-iodobenzaldehyde

収率 54.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   ろ過the solid is then filtered off
2. 2
   その他the solvent is evaporated off
3. 3
   その他The residual oil is chromatographed on silica gel (8/2 heptane/ethyl acetate)
4. 4
   その他The oil obtained
5. 5
   その他is crystallized from pentane

実験手順

7.8 g (90 mmol, 5 eq) of manganese oxide are added to a solution of 6.5 g (17.98 mmol, 1 eq) of (3-benzyloxy-4-iodophenyl)methanol in 50 mL of dichloromethane. The reaction medium is stirred for 12 hours at room temperature, and the solid is then filtered off and the solvent is evaporated off. The residual oil is chromatographed on silica gel (8/2 heptane/ethyl acetate). The oil obtained is crystallized from pentane. 3.25 g of 3-benzyloxy-4-iodobenzaldehyde are obtained. Yield=54% for the three steps c, d and e.

出典