反応 #3375

反応方程式

4-mercapto-2-piperidin-1-yl-pyrimidine-5-carboxylic acid amide

iodine

→

title compound

収率 69.6%

6-Piperidin-1-yl-isothiazolo[5,4-d]pyrimidin-3-one

収率 69.6%

反応条件

実験手順

Using the procedure of Example 20, 20.8 g (87.4 mmol) of 4-mercapto-2-piperidin-1-yl-pyrimidine-5-carboxylic acid amide were treated with 22.2 g (87.4 mmol) of iodine to give 14.37 g of the title compound after recrystallization from dimethylformamide, mp 268°-269° C.

出典