反応 #3371

反応方程式

4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid phenethyl-amide

iodine

→

title compound

収率 71.5%

2-phenethyl-6-phenyl-isothiazolo[5,4-d]pyrimidin-3-one

収率 71.5%

反応条件

実験手順

Using the procedure of Example 20, 2.0 g (5.96 mmol) of 4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid phenethyl-amide were treated with 1.66 g (6.56 mmol) of iodine to give 1.42 g of the title compound after recrystallization from isopropanol, mp 144°-147° C.

出典