反応 #337073

ord-6e4068646461438e9cf5b04a8a795c08

反応方程式

CC1CN(c2nc3c(C(=O)[O-])cccc3o2)CCN1C(=O)OC(C)(C)C.[Li+]
lithium 2-(4-(tert-butoxycarbonyl)-3-methylpiperazin-1-yl)benzoxazole-4-carboxylate
CN1C2CCCC1CC(N)C2.Cl.Cl
9-methyl-9-azabicyclo[3.3.1]nonan-3-amine dihydrochloride
→
CC1CN(c2nc3c(C(=O)NC4CC5CCCC(C4)N5C)cccc3o2)CCN1C(=O)OC(C)(C)C
tert-butyl 2-methyl-4-(4-(9-methyl-9-azabicyclo[3.3.1]nonan-3-ylcarbamoyl)benzoxazol-2-yl)piperazine-1-carboxylate

反応物

CC1CN(c2nc3c(C(=O)[O-])cccc3o2)CCN1C(=O)OC(C)(C)C.[Li+]
lithium 2-(4-(tert-butoxycarbonyl)-3-methylpiperazin-1-yl)benzoxazole-4-carboxylate
CN1C2CCCC1CC(N)C2.Cl.Cl
9-methyl-9-azabicyclo[3.3.1]nonan-3-amine dihydrochloride

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Following general procedure GP-C1, lithium 2-(4-(tert-butoxycarbonyl)-3-methylpiperazin-1-yl)benzoxazole-4-carboxylate and 9-methyl-9-azabicyclo[3.3.1]nonan-3-amine dihydrochloride were coupled to provide tert-butyl 2-methyl-4-(4-(9-methyl-9-azabicyclo[3.3.1]nonan-3-ylcarbamoyl)benzoxazol-2-yl)piperazine-1-carboxylate. MS consistent.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07863271B2uspto-grants-2011_01