反応 #336944
ord-95f15adcd3274c0687acf6b809a83c71
反応方程式
反応条件
温度
40°CELSIUS
詳細条件
See reaction.notes.procedure_details.
後処理
- 1抽出The aqueous layer was extracted with EtOAc twice
- 2その他The combined organic layers were dried
- 3ろ過filtered
- 4濃縮concentrated
- 5その他The resulting white solid was collected
- 6その他dried in vacuum oven at 50° C. for 18 h
実験手順
7-Benzyl-3,7-dihydro-1H-purine-2,6-dione (5.0 g, 21 mmol) was mixed with sodium carbonate (3.3 g, 31 mmol) and 1-iodopentane (4.0 mL, 31 mmol) in DMF (60 mL). After being stirred at 40° C. for 18 h, the reaction mixture was diluted with water and EtOAc. The aqueous layer was extracted with EtOAc twice. The combined organic layers were dried, filtered and concentrated. The resulting white solid was collected and dried in vacuum oven at 50° C. for 18 h to provide the desired product (2.84 g, 44% yield). LCMS calculated for C17H21N4O2(M+H): 313.2. found: 313.2.