反応 #336133

反応方程式

N-methyl-N-[2-[[(4-methylphenyl)phenyl-methyl]thio]ethyl]-1,4-butanediamine

N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-O-phenyl-isourea

→

N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-N"-[4-[N-[2-[[(4-methylphenyl)phenyl-methyl]thio]ethyl]N-methylamino]butyl]guanidine

反応条件

後処理

1. 1
   その他Preparation
2. 2
   その他Working up by chromatography analogously to Example 1 yields the
3. 3
   その他purified title compound in the form of a viscous oil
4. 4
   その他recrystallised from ether/isopropanol

実験手順

Preparation is effected analogously to Example 1, using 0.87 g (2.5 mmol) of N-methyl-N-[2-[[(4-methylphenyl)phenyl-methyl]thio]ethyl]-1,4-butanediamine and 0.95 g (2.5 mmol) of N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-O-phenyl-isourea as starting materials. Working up by chromatography analogously to Example 1 yields the purified title compound in the form of a viscous oil; MS (+FAB method): m/z (rel. int.[%])=624 ([M+H]+,6), 181 (100); IR (KBr): 2161 cm-1 (C≡N). For analytical purposes a sample is converted into the O,O'-ditoluoyltartaric acid salt and recrystallised from ether/isopropanol; m.p.: 134°-140° C. with decomposition.

出典