反応 #335715

反応方程式

3-(3-thienyl)-1-piperazine carboxylic acid, ethyl ester

lithium aluminum hydride

→

4-methyl-2-(3-thienyl)piperazine

収率 93.4%

溶媒

ether

ether

反応条件

後処理

1. 1
   温度The mixture was refluxed for 12 hours
2. 2
   その他the product recovered

実験手順

A solution of 1.20 g of 3-(3-thienyl)-1-piperazine carboxylic acid, ethyl ester in 100 ml of ether was added to a suspension of 380 mg of lithium aluminum hydride in 50 ml of ether. The mixture was refluxed for 12 hours and the product recovered, giving 850 mg of 4-methyl-2-(3-thienyl)piperazine.

出典