反応 #335671

反応方程式

2-(2,5-dimethyl-3-thienyl)piperazine

7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

→

desired product

収率 46.7%

7-[3-(2,5-Dimethyl-3-thienyl)-1-piperazinyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

収率 46.7%

溶媒

pyridine

反応条件

後処理

1. 1
   温度was heated for 48 hours
2. 2
   温度cooled
3. 3
   ろ過filtered
4. 4
   その他The filtrate was evaporated under reduced pressure
5. 5
   その他the residue triturated with chloroform:methanol (9:1)

実験手順

A mixture of 2.35 g of 2-(2,5-dimethyl-3-thienyl)piperazine and 1.076 g of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid in 10 ml of pyridine was heated for 48 hours, then cooled and filtered. The filtrate was evaporated under reduced pressure and the residue triturated with chloroform:methanol (9:1),. giving 800 mg of the desired product, mp 248°-250° C.

出典