反応 #3347

反応方程式

benzylbromide

5,5-dimethyl-2,4-dithiohydantoin

→

2-benzylthio-5,5-dimethylimidazolin-4-thione

溶媒

ethanol

反応条件

後処理

1. 1
   濃縮concentrated in vacuo
2. 2
   workup.ADDITIONThe residue was treated
3. 3
   その他purified by column chromatography (CHCl3)
4. 4
   その他Recrystallization from diethyl ether-n-hexane

実験手順

Initially, 1.91 mL of benzylbromide was added to a solution of 1.6 g of 5,5-dimethyl-2,4-dithiohydantoin in 50 mL of ethanol (EtOH). The reaction mixture was stirred at the room temperature for one hour, and concentrated in vacuo. The residue was treated following the procedure used in Example 62, and purified by column chromatography (CHCl3). Recrystallization from diethyl ether-n-hexane gave 2-benzylthio-5,5-dimethylimidazolin-4-thione in the form of a needle-like crystal. The yield of this compound was 0.87 g with a yield ratio of 34.8%, and the melting point was 133°-134° C.

出典