反応 #334341

反応方程式

N-methyl-9-azabicyclo-[3.3.1]-nonan-3-one oxime

ammonium acetate

→

3-amino-9-methyl-9-azabicyclo-[3.3.1]-nonane

収率 90.0%

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過The mixture was filtered
2. 2
   その他evaporated in vacuo
3. 3
   workup.DISSOLUTIONdissolved in dilute hydrochloric acid
4. 4
   抽出extracted into ethyl acetate
5. 5
   乾燥The combined organic layers were dried (K2CO3)
6. 6
   ろ過filtered
7. 7
   その他evaporated in vacuo

実験手順

N-methyl-9-azabicyclo-[3.3.1]-nonan-3-one oxime (3.25 g., 0.02 mole) was dissolved in ethanol and hydrogenated over Raney nickel in the presence of ammonium acetate at 300 p.s.i. at 50° C. for 24 hours. The mixture was filtered, evaporated in vacuo, dissolved in dilute hydrochloric acid, basified and extracted into ethyl acetate. The combined organic layers were dried (K2CO3), filtered and evaporated in vacuo to yield 3-amino-9-methyl-9-azabicyclo-[3.3.1]-nonane (2.67 g., 90%), used without further purification.

出典