反応 #334272

反応方程式

sodium hydride

4-hydroxycarbonylbutyl-triphenylphosphonium bromide

5-(4-chlorobenzyl)-thiophene-2-aldehyde

→

6-[5-(4-Chlorobenzyl)-thien-2-yl]-hex-5-enoic acid

溶媒

dimethylsulphoxide

dimethylsulphoxide

dimethylsulphoxide

反応条件

実験手順

This compound is prepared analogously to Example 7b from: 6.3 g of sodium hydride (=7.8 g of 80% strength mineral oil suspension) in 180 ml of dimethylsulphoxide, 57.9 g of 4-hydroxycarbonylbutyl-triphenylphosphonium bromide in 180 ml of dimethylsulphoxide and 25.0 g of 5-(4-chlorobenzyl)-thiophene-2-aldehyde in 20 ml of dimethylsulphoxide.

出典