反応 #334229

反応方程式

3-methylpiperidine

4-chlorobutyronitrile

→

4-(3-methylpiperidino)-butyronitrile

収率 70.3%

溶媒

benzene

反応条件

後処理

1. 1
   その他the precipitate was removed by filtration
2. 2
   その他The residue from the evaporation
3. 3
   workup.DISTILLATIONwas purified by distillation under reduced pressure

実験手順

In a solution under reflux of 58.6 ml (0.50 mole) of 3-methylpiperidine in 65 ml of benzene, were run in 25 minutes 27.2 g (0.25 mole) of 4-chlorobutyronitrile Reflux was continued for 2h, the precipitate was removed by filtration and the filtrate brought to dryness under reduced pressure. The residue from the evaporation was purified by distillation under reduced pressure to give 29.2 g (yields=70.3%) of 4-(3-methylpiperidino)-butyronitrile which was in the form of a colourless oil. Boiling point 5-6 mmHg =100° C.

出典