反応 #332407

反応方程式

3-(methylthio)aniline

3-(trifluoromethyl)benzaldehyde

2-Oxobutanoic acid

→

3-methyl-7-(methylthio)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

収率 16.4%

溶媒

ethanol

反応条件

後処理

1. 1
   温度at reflux for 1 h
2. 2
   温度at reflux for additional 3 h
3. 3
   workup.STIRRINGstirred overnight
4. 4
   ろ過The mixture was filtered
5. 5
   その他the solid material collected

実験手順

A solution of 3-(methylthio)aniline (1.392 g, 10.0 mmol) and 3-(trifluoromethyl)benzaldehyde (1.741 g, 10.0 mmol) in ethanol (30 mL) was stirred at reflux for 1 h. 2-Oxobutanoic acid (1.021 g, 10.0 mmol) was added portionwise. The reaction mixture was stirred at reflux for additional 3 h, cooled to room temperature, and stirred overnight. The mixture was filtered and the solid material collected to give 3-methyl-7-(methylthio)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid (0.62 g, 16% yield). MS (m/z) 378.0 (M+H+).

出典