反応 #331944

反応方程式

1,2-Diethylbenzene

propionyl chloride

AlCl3

sulphuric acid

→

3-chloro-1-(3,4-diethylphenyl)-1-propanone

溶媒

nitromethane

反応条件

後処理

1. 1
   抽出The aqueous phase is extracted with ether
2. 2
   抽出the combined organic phases extracted with 2N HCl and saturated aqueous NaCl
3. 3
   workup.ADDITIONThe organic phase is further treated with activated charcoal, magnesium sulphate
4. 4
   ろ過filtered
5. 5
   その他the solvent removed in vacuo

実験手順

1,2-Diethylbenzene (10.9 g, 74.6 mmol) and propionyl chloride (9.7 g, 74.6 mmol) are added dropwise to AlCl3 (22.3 g, 167.8 mmol) in nitromethane (75 mL) over 30 min. The reaction mixture is stirred at room temperature for 2 hours, after which 70 g of ice and 14 mL concentrated sulphuric acid are added. The aqueous phase is extracted with ether, and the combined organic phases extracted with 2N HCl and saturated aqueous NaCl. The organic phase is further treated with activated charcoal, magnesium sulphate, and filtered, and the solvent removed in vacuo.

出典