反応 #3319

反応方程式

(4-ethylamino-2-phenylamino-pyrimidin-5-yl)methanol

→

4-ethylamino-2-phenylamino-pyrimidine-5-carbaldehyde

収率 99.0%

溶媒

chloroform

反応条件

後処理

1. 1
   ろ過the mixture was filtered through a pad of Celite
2. 2
   洗浄washing with chloroform
3. 3
   濃縮The filtrate was concentrated in vacuo

実験手順

To a solution of (4-ethylamino-2-phenylamino-pyrimidin-5-yl)methanol (173 mg, 0.71 mmol) in 15 mL of chloroform was added manganese oxide (600 mg, 6.89 mmol). After stirring at room temperature overnight, the mixture was filtered through a pad of Celite, washing with chloroform. The filtrate was concentrated in vacuo to give 170 mg (99%) of 4-ethylamino-2-phenylamino-pyrimidine-5-carbaldehyde; mp 155°-157° C.

出典