反応 #3317

反応方程式

4-ethylamino-2-methylthio-5-pyrimidinemethanol

→

4-ethylamino-2-methylthio-5-formylpyrimidine

収率 97.8%

溶媒

chloroform

反応条件

後処理

1. 1
   workup.STIRRINGStirring
2. 2
   workup.WAITwas continued for 4.5 hours
3. 3
   ろ過The mixture was then filtered
4. 4
   洗浄through celite washing with chloroform
5. 5
   濃縮The filtrate was concentrated in vacuo

実験手順

To 4-ethylamino-2-methylthio-5-pyrimidinemethanol (6.44 g, 32.4 mmol) in 600 mL of chloroform was added manganese oxide (21.0 g, 241 mmol) over 3 minutes. The suspension was stirred at room temperature for 2 hours, and an additional 5.5 g of manganese oxide was added. Stirring was continued for 4.5 hours. The mixture was then filtered through celite washing with chloroform. The filtrate was concentrated in vacuo to give 6.25 g (97%) of 4-ethylamino-2-methylthio-5-formylpyrimidine; mp 58°-61° C.

出典