反応 #330741

反応方程式

6-(3,4-dichlorophenyl)-5-methylpyridazin-3(2H)-one

phosphoryl trichloride

→

3-chloro-6-(3,4-dichlorophenyl)-5-methylpyridazine

反応条件

後処理

1. 1
   温度cooled to room temperature
2. 2
   workup.ADDITIONpoured onto ice water
3. 3
   その他The formed precipitate is separated
4. 4
   洗浄washed with water
5. 5
   その他dried

実験手順

6-(3,4-dichlorophenyl)-5-methylpyridazin-3(2H)-one (500 mg) is added stepwise to phosphoryl trichloride (1.8 ml). The reaction mixture is heated to 100° C. for 1 hour, then cooled to room temperature and poured onto ice water. The formed precipitate is separated, washed with water and dried to give 3-chloro-6-(3,4-dichlorophenyl)-5-methylpyridazine (509 mg).

出典