反応 #330366

反応方程式

2,4-dichloropyrimidine-5-carbonitrile

NH3 MeOH

→

title compound

収率 39.0%

2-Amino-4-chloropyrimidine-5-carbonitrile

収率 39.0%

溶媒

MeOH

反応条件

後処理

1. 1
   ろ過was filtered
2. 2
   洗浄washed with MeOH

実験手順

To a stirred solution of 2,4-dichloropyrimidine-5-carbonitrile (500 mg, 2.87 mmol) in MeOH (5 mL) was added 2M NH3/MeOH (5 mL). After stirring for 20 min the resulting precipitate was filtered and washed with MeOH to afford the title compound as a white solid (173 mg, 39%). LCMS (Method C): RT 1.91 min [M+H]+ 155.1. 1H NMR (DMSO-d6, 400 MHz): δ 8.68 (1H, s), 8.23 (2H, br s)

出典