反応 #329346

反応方程式

crude product

2′-Amino-6-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-6′-mercapto-3,4′-bipyridine-3′,5′-dicarbonitrile

4-(chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole

sodium bicarbonate

→

2′-Amino-6′-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}thio)-6-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-3,4′-bipyridine-3′,5′-dicarbonitrile

溶媒

DMF

反応条件

後処理

1. 1
   その他The mixture is then purified directly by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5)

実験手順

200 mg (0.32 mmol) of the crude product from example 31A, 90 mg (0.36 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole and 82 mg (0.97 mmol) of sodium bicarbonate are added to 3.4 ml of dry DMF, and the mixture is stirred at RT for 20 h. The mixture is then purified directly by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

出典