反応 #328741

反応方程式

tert-butyl 3-oxopyrrolidine-1-carboxylate

DMF-DMA

→

tert-Butyl (3Z)-3-[(dimethylamino)methylene]-4-oxopyrrolidine-1-carboxylate

反応条件

後処理

1. 1
   温度The solution was cooled
2. 2
   その他evaporated under reduced pressure
3. 3
   workup.ADDITIONthe resulting orange solid was treated with hexane (200 mL)
4. 4
   温度cooled in the refrigerator over the weekend
5. 5
   ろ過The resulting brownish-yellow solid was collected by filtration
6. 6
   その他dried
7. 7
   その他used in the next setp without further purification

実験手順

A solution of tert-butyl 3-oxopyrrolidine-1-carboxylate (40 g, 216 mmol) was treated with DMF-DMA (267 g, 2241 mmol) and heated at 105° C. for 40 min. The solution was cooled and evaporated under reduced pressure and the resulting orange solid was treated with hexane (200 mL) and cooled in the refrigerator over the weekend. The resulting brownish-yellow solid was collected by filtration, dried and used in the next setp without further purification.

出典