反応 #328730

反応方程式

1-(tert-butoxylcarbonyl)-3-pyrrolidone

N,N-dimethylformamide dimethyl acetal

→

tert-Butyl 3-[(dimethylamino)methylene]-4-oxopyrrolidine-1-carboxylate

反応条件

後処理

1. 1
   濃縮concentrated under reduced pressure
2. 2
   workup.DISSOLUTIONThe residue was redissolved in a minimum amount of dichloromethane
3. 3
   その他triturated with hexane
4. 4
   その他to yield a yellow precipitate

実験手順

A solution of 1-(tert-butoxylcarbonyl)-3-pyrrolidone (4.10 g) and N,N-dimethylformamide dimethyl acetal (30.0 mL) was heated to 140° C. for 1 h. The resulting mixture was cooled to room temperature and concentrated under reduced pressure. The residue was redissolved in a minimum amount of dichloromethane and triturated with hexane to yield a yellow precipitate. LC-MS=241.1 (M+1).

出典