反応 #327656

反応方程式

4-[(4-nitro-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine

→

4-[(4-amino-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine

収率 95.5%

溶媒

THF

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   濃縮concentrated

実験手順

In a round-bottom flask was added 4-[(4-nitro-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine (500 mg, 1.3 mmol), Palladium on carbon (50 mg, 10%), and THF (30 mL). The mixture was stirred under a hydrogen atmosphere for 2 h, then filtered, concentrated to afford 4-[(4-amino-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine (450 mg).

出典