反応 #3259

反応方程式

sodium 2-ethoxyethoxide

sodium

2,4-diamino-5-pyrimidinecarboxaldehyde

2,6-dichlorophenylacetonitrile

→

2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine

溶媒

2-ethoxyethanol

反応条件

後処理

1. 1
   その他(Prepared by the method of U.S
2. 2
   温度The mixture was heated
3. 3
   温度at reflux for 4 hours
4. 4
   ろ過the precipitated product was filtered
5. 5
   洗浄washed with diethyl ether

実験手順

(Prepared by the method of U.S. Pat. No. 3,534,039). To a solution of sodium 2-ethoxyethoxide prepared from 0.14 g of sodium and 60 mL of 2-ethoxyethanol was added 2.07 g of 2,4-diamino-5-pyrimidinecarboxaldehyde, and 2.79 g of 2,6-dichlorophenylacetonitrile. The mixture was heated at reflux for 4 hours, allowed to cool to room temperature, and the precipitated product was filtered and washed with diethyl ether to give 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine; mp 325°-332° C.

出典