反応 #325831

反応方程式

acetic acid methyl ester

3-bromo-2-chloro-5-ethanesulfonyl-pyridine

methyl ester

2-(4-fluoro-benzylidene)-3-methyl-succinic acid 1-methyl ester

→

[4-(3-bromo-5-ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

収率 73.9%

反応条件

実験手順

Starting with 6-fluoro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester (124 mg, 0.50 mmol) and 3-bromo-2-chloro-5-ethanesulfonyl-pyridine (157 mg, 0.55 mmol), using a method analogous to the one described for the methyl ester of example 2-1, [4-(3-bromo-5-ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (183 mg, 73.9%) was obtained as a white solid.

出典