反応 #325662

反応方程式

1-(tert-butyl)-2-bromo-4-nitrobenzene

3-buten-1-ol

→

4-(2-tert-Butyl-5-nitro-phenyl)-but-3-en-1-ol

溶媒

toluene

反応条件

後処理

1. 1
   その他was degassed with nitrogen
2. 2
   温度The next day, the reaction mixture was cooled to RT
3. 3
   ろ過filtered
4. 4
   濃縮concentrated in vacuo
5. 5
   洗浄The crude was eluted on a silica gel column with 15% to 22% EtOAc/hexanes gradient system
6. 6
   その他to yield a yellow-brown oil

実験手順

A mix of 1-(tert-butyl)-2-bromo-4-nitrobenzene (3.652 g), TEA (5.92 ml), 3-buten-1-ol (5.48 ml), Pd(OAc)2 (32 mg), Pd(PPh3)4 (327 mg) and toluene (40 ml) was degassed with nitrogen and heated in a sealed vessel for 16 h at 120° C. The next day, the reaction mixture was cooled to RT, filtered, and concentrated in vacuo. The crude was eluted on a silica gel column with 15% to 22% EtOAc/hexanes gradient system to yield a yellow-brown oil.

出典