反応 #3249

反応方程式

ethanol

2-amino-4-methoxybenzophenone

diethylmalonate

→

title compound

収率 90.2%

1,2-dihydro-7-methoxy-4-phenyl-2-oxo-3-quinoline carboxylic acid ethyl ester

収率 90.2%

反応条件

後処理

1. 1
   温度The reaction mixture was cooled by air
2. 2
   その他to obtain a precipitated crystal
3. 3
   ろ過by filtration
4. 4
   その他The crystal obtained
5. 5
   洗浄was washed with ethanol

実験手順

A mixture of 2-amino-4-methoxybenzophenone (20 g, 88 mmol), diethylmalonate (26.7 ml, 176 mmol), 1,8-diazabicyclo[5,2,0]-undeca-7-en (DBU) (0.66 ml, 4.4 mmol) was stirred with heat at 160° C. for 2 hours. The reaction mixture was cooled by air. To the cooled mixture was added ethanol (30 ml) to obtain a precipitated crystal by filtration. The crystal obtained was washed with ethanol to give 25.7 g (yield: 90.2%) of the title compound.

出典