反応 #324361

反応方程式

Tolterodine tartrate

→

Tolterodin

溶媒

water

反応条件

後処理

1. 1
   その他Dry pellet cores
2. 2
   workup.DISSOLUTIONWithin first hour almost 50% dissolves, however between 7 and 16 hours
3. 3
   workup.DISSOLUTIONless dissolves

実験手順

Tolterodine tartrate, microcrystalline cellulose and part of ethylcellulose are blended with small amount of water into homogeneous blend from which pellet cores are made by extrusion and spheronization. Dry pellet cores are coated with the coating dispersion of Example 8. Within first hour almost 50% dissolves, however between 7 and 16 hours less dissolves as compared to Example 2.

出典