反応 #324356

反応方程式

aniline

N,N-diisopropylethylamine

propane sultone

→

di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate

収率 94.0%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   workup.ADDITIONethylacetate was added
3. 3
   ろ過The precipitated DIPEA bromide was filtered off
4. 4
   その他the filtrate was evaporated
5. 5
   workup.ADDITIONThe residue was treated with ether

実験手順

A mixture of aniline (7 mmol), N,N-diisopropylethylamine (DIPEA, 18 mmol) and propane sultone (16 mmol) was heated in a pressure tube in 10 mL of acetonitrile at 120-130° C. for 9 h under argon atmosphere. The solvent was evaporated and ethylacetate was added. The precipitated DIPEA bromide was filtered off and the filtrate was evaporated. The residue was treated with ether to give di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate as a white or pinky-white solid. Yield: 94%.

出典