反応 #324

ord-b387923b7ccc41128cba74368ffb7dd0

反応方程式

CC(C)OCC1CN(C)Cc2ccc(Cl)nc2O1
CC(C)OCC1CN(C)Cc2ccc
COc1cc(N)ccc1-n1cnc(C)c1
COc1cc(N)ccc1-n1cnc(
COc1cc(Nc2ccc3c(n2)OC(COC(C)C)CN(C)C3)ccc1-n1cnc(C)c1
COc1cc(Nc2ccc3c(n2)O
収率 5.3%

溶媒

反応条件

温度
100°CELSIUS

実験手順

8-chloro-2-(isopropoxymethyl)-4-methyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (0.157 g, 0.58 mmol), 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (0.118 g, 0.58 mmol), Palladium acetate (0.013 g, 0.06 mmol), 2-(Dicyclohexylphosphino)biphenyl (0.020 g, 0.06 mmol) and Cesium carbonate (0.567 g, 1.74 mmol) were placed in a microwave vial. The mixture was capped and flushed with argon. 1,2-dimethoxyethane (5 mL) was added and the mixture was run in a microwave for 60 minutes at 100°C. Very little product. Added 0.1 eq ligand and palladium acetate, flushed with argon and run in the microwave at 100°C for 60 min. Still have a lot of startingmaterial (oxazepine) left. Added 0.1 eq ligand and palladium acetate, flushed with argon and run in the microwave at 100°C for 60 min. The reaction mixture was filtrated through Celite and washed with dichloromethane. The filtrate was concentrated and the crude product was purified by preparative chromatography. The productcontaining fractions were pooled, concentrated and the residue was partitioned between sat. NaHCO3 (aq) and dichloromethane. The organic layer was separated by a Phase Separator and concentrated giving 2-(isopropoxymethyl)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine (0.013 g, 5.28 %).

出典

750 AstraZeneca ELN dataset