反応 #323846

反応方程式

α-oxo-2-nitrobenzenepropanoic acid

sodium borohydride

hydrochloric acid

→

titled product

α-Hydroxy-2-Nitrobenzenepropanoic Acid

溶媒

water

反応条件

後処理

1. 1
   温度to maintain a temperature between 45° and 50°
2. 2
   温度cooling
3. 3
   その他gave crude product
4. 4
   その他Recrystallization from water

実験手順

To a magnetically stirred suspension of α-oxo-2-nitrobenzenepropanoic acid (5.00 g) in water (75 ml) containing 1 drop of decyl alcohol was added sodium borohydride (2.50 g) in portions to maintain a temperature between 45° and 50°. The resulting solution was then left at room temperature for 21/2 hours. The solution was acidified with concentrated hydrochloric acid and seeded. Stirring and cooling gave crude product; yield 5.01 g, m.p. 84°-90°. Recrystallization from water gave titled product; yield 2.63 g (52%), m.p. 95°-98° with spectral data as above.

出典