反応 #323747

反応方程式

resultant compound

(S)-5-Methyl-3-[(toluenesulfonyl) amino]-2-hexanone

t-butoxymethyl lithium

water

→

desired compound

収率 85.0%

1-t-Butyloxy-2,5-dimethyl-2-hydroxy-3-(toluenesulfonyl) aminohexane

収率 85.0%

溶媒

THF

反応条件

後処理

1. 1
   抽出Acidification with 0.1M H3PO4, extraction into ether
2. 2
   洗浄washing with brine
3. 3
   その他drying
4. 4
   その他evaporating

実験手順

To a -78° C. solution of the resultant compound of Example 57 (1.0 g, 3.5 mmol) in dry THF (7 ml) was added 3 equivalent, of t-butoxymethyl lithium [E. J. Corey and T. M. Eckridge, Tetrahedron Letters, 3165 (1983)]. The mixture was warmed to room temperature for 4 hours and then poured into water. Acidification with 0.1M H3PO4, extraction into ether, washing with brine, drying, and evaporating gave 1.1 g, (85%) of the desired compound. Mass spectrum: M+ =371.

出典