反応 #323111

反応方程式

4-(2,3-epoxypropoxy)benzaldehyde

n-butylamine

→

4-(3-n-butylamino-2-hydroxypropoxy)benzaldehyde

反応条件

後処理

1. 1
   温度the resulting solution is refluxed 17 hours
2. 2
   その他The excess n-butylamine is removed under reduced pressure (20 mm)
3. 3
   workup.DISSOLUTIONThe oil is dissolved in 6N hydrochloric acid (30 ml.)
4. 4
   温度the solution is heated on a steam bath for 40 minutes
5. 5
   workup.ADDITIONThe hot acidic solution is poured into a hot saturated aqueous sodium carbonate solution with nitrogen bubbling through it
6. 6
   抽出The basic solution is extracted with chloroform
7. 7
   乾燥The chloroform is dried over sodium sulfate
8. 8
   濃縮concentrated

実験手順

To 4-(2,3-epoxypropoxy)benzaldehyde (8.9 gms., 0.05 m) is added n-butylamine (30 ml.) and the resulting solution is refluxed 17 hours. The excess n-butylamine is removed under reduced pressure (20 mm). The oil is dissolved in 6N hydrochloric acid (30 ml.) and the solution is heated on a steam bath for 40 minutes. The hot acidic solution is poured into a hot saturated aqueous sodium carbonate solution with nitrogen bubbling through it. The basic solution is extracted with chloroform. The chloroform is dried over sodium sulfate and concentrated to yield 4-(3-n-butylamino-2-hydroxypropoxy)benzaldehyde, as an oil.

出典