反応 #323040

反応方程式

ethanol

2-furancarboxylic acid

2-amino-7-methoxy-1,8-naphthyridine

→

N-(7-Methoxy-1,8-naphthyridin-2-yl)-2-furancarboxamide

収率 83.7%

溶媒

water

反応条件

後処理

1. 1
   workup.DISSOLUTIONis dissolved
2. 2
   その他the crystallised solid is separated by filtration
3. 3
   洗浄washed with ethanol (2×10 cc)
4. 4
   その他dried at 45° C. under reduced pressure (0.067 kPa)

実験手順

The procedure is similar to that described in Example 1, but starting with 2-furancarboxylic acid (8.95 g), N,N'-carbonyldiimidazole (12.8 g) and 2-amino-7-methoxy-1,8-naphthyridine (10.5 g). The product produced by precipitation in water (15.5 g; m.p. 199° C.) is dissolved in boiling ethanol (500 cc). After 2 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with ethanol (2×10 cc) and dried at 45° C. under reduced pressure (0.067 kPa). N-(7-Methoxy-1,8-naphthyridin-2-yl)-2-furancarboxamide (13.5 g) is produced, m.p. 201° C.

出典