反応 #322834

反応方程式

sodium carbonate

N,N-diethylethylenediamine

4-(7-Chloro-4-cinnolinylamino)benzenesulphonyl chloride hydrochloride

→

title compound

4-[7-Chloro-4-cinnolinylamino]-N-(2-diethylaminoethyl) benzenesulphonamide

溶媒

chloroform

反応条件

後処理

1. 1
   workup.STIRRINGThe mixture was stirred at room temperature for 11/2 hours
2. 2
   ろ過filtered
3. 3
   その他The filtrate was evaporated
4. 4
   その他to give a residue that
5. 5
   その他crystallised from ethanol

実験手順

A mixture of anhydrous sodium carbonate (3.08 g) and N,N-diethylethylenediamine (0.43 ml) in chloroform (30 ml) was vigorously stirred at 5° C. and treated with 4-(7-Chloro-4-cinnolinylamino)benzenesulphonyl chloride hydrochloride (1.0 g). The mixture was stirred at room temperature for 11/2 hours and then filtered. The filtrate was evaporated to give a residue that crystallised from ethanol to give the title compound (0.456 g), m.p. 175°-76° C.

出典