反応 #3223

反応方程式

methyl 2-(tert-butoxycarbonylamino)-4,6-dichloro-5-methoxybenzoate

trifluoroacetic acid

→

title compound

収率 87.0%

Methyl 2-amino-4,6-dichloro-5-methoxybenzoate

収率 87.0%

溶媒

methylene chloride

反応条件

後処理

1. 1
   洗浄The reaction mixture was then washed with saturated aqueous sodium bicarbonate, drie (MgSO4)
2. 2
   ろ過filtered
3. 3
   濃縮concentrated

実験手順

A solution o#methyl 2-(tert-butoxycarbonylamino)-4,6-dichloro-5-methoxybenzoate (2.3 g, 6.6 mM) and trifluoroacetic acid (6.0 g, 53 mM) in methylene chloride (23 mL) was stirred at room temperature for 1.5 hr. The reaction mixture was then washed with saturated aqueous sodium bicarbonate, drie (MgSO4), filtered and concentrated to obtain (87%) the title compound as a yellow oil; MS(CI): 250 (M+H).

出典