反応 #322060

反応方程式

potassium hydroxide

4-amino-5-formyl-2-methylpyrimidine

4-fluoroacetophenone

→

7-(4-Fluorophenyl)-2-methylpyrido[2,3-d]pyrimidine

収率 50.0%

溶媒

methanol

反応条件

後処理

1. 1
   その他a homogeneous solution being formed
2. 2
   その他the solid formed
3. 3
   その他was isolated
4. 4
   その他was recrystallized from ethanol

実験手順

15 ml of 40% strength by weight aqueous potassium hydroxide solution were slowly added to a suspension of 30.1 g (0.22 mol) of 4-amino-5-formyl-2-methylpyrimidine and 31.7 g (0.23 mol) of 4-fluoroacetophenone in 395 ml of methanol at 20°-25° C., a homogeneous solution being formed. After the mixture had been stirred for 20 hours at about 20° C., the solid formed was isolated and was recrystallized from ethanol. Yield: 50%; mp.>200° C.

出典