反応 #321649

反応方程式

thiophene-2-boronic acid

methyl-4-bromobenzoate

→

2-(4-methoxycarbonylphenyl)thiophene

収率 65.0%

反応条件

後処理

1. 1
   その他2-(4-methoxycarbonylphenyl)thiophene was prepared in the same manner
2. 2
   その他Purification by column chromatography

実験手順

2-(4-methoxycarbonylphenyl)thiophene was prepared in the same manner as described in Example 32C from thiophene-2-boronic acid (1.0 g, 7.81 mmol) and methyl-4-bromobenzoate (1.68 g, 7.81 mmol). Purification by column chromatography using 2% ethyl acetate/hexanes gave 1.1 g of 2-(4-methoxycarbonylphenyl)thiophene as a white solid (65% yield).

出典