反応 #321635

反応方程式

3,5-bis(trifluoromethyl)benzeneboronic acid

N-[5-bromothiophene-2-sulfonyl]pyrrole

→

N-{5-[3,5-bis(trifluoromethyl)phenyl]thiophene-2-sulfonyl}pyrrole

収率 93.0%

反応条件

後処理

1. 1
   その他Purification by column chromatography

実験手順

N-{5-[3,5-bis(trifluoromethyl)phenyl]thiophene-2-sulfonyl}pyrrole was prepared in the same manner as described in Example 32C from 3,5-bis(trifluoromethyl)benzeneboronic acid (619 mg, 2.26 mmol) and N-[5-bromothiophene-2-sulfonyl]pyrrole (60 mg, 2.05 mmol). Purification by column chromatography using 2% ethyl acetate/hexanes gave the pure sulfonamide as a white solid in 93% yield.

出典