反応 #321630

反応方程式

4-trifluoromethylbenzene boronic acid

N-(5-bromothiophene sulfonyl)pyrrole

→

N-{5-[4-(trifluoromethyl)phenyl]thiophene-2-sulfonyl}pyrrole

収率 75.0%

反応条件

後処理

1. 1
   その他Purification by column chromatography

実験手順

N-{5-[4-(trifluoromethyl)phenyl]thiophene-2-sulfonyl}pyrrole was prepared in the same manner as described in Example 32C using 4-trifluoromethylbenzene boronic acid and N-(5-bromothiophene sulfonyl)pyrrole. Purification by column chromatography using 2% ethyl acetate/hexanes gave the pure sulfonamide as a white powder in 75% yield.

出典