反応 #321566

反応方程式

4-propylphenyl boronic acid

N-(5-bromothiophenesulfonyl)pyrrole

→

N-[5-(4-propylphenyl)thiophene-2-sulfonyl]pyrrole

収率 55.0%

反応条件

後処理

1. 1
   その他Purification by column chromatography

実験手順

N-[5-(4-propylphenyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 33C, from 4-propylphenyl boronic acid and N-(5-bromothiophenesulfonyl)pyrrole. Purification by column chromatography using 10% ethyl acetate/hexanes gave the pure sulfonamide as a white solid in 55% yield, m.p. 106°-108° C.

出典