反応 #321563

反応方程式

4-isopropylphenyl boronic acid

N-(5-bromothiophene sulfonyl)-pyrrole

→

N-[5-(4-isopropylphenyl)thiophene-2-sulfonyl]pyrrole

収率 84.0%

反応条件

後処理

1. 1
   その他Purification by column chromatography

実験手順

N-[5-(4-isopropylphenyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 33C, from 4-isopropylphenyl boronic acid and N-(5-bromothiophene sulfonyl)-pyrrole. Purification by column chromatography using 10% ethyl acetate/hexanes gave the pure sulfonamide as an off white colored solid in 84% yield, m.p. 112°-114° C.

出典