反応 #320048

反応方程式

sodium boron hydride

7-chloro-6-fluoro-2-formylquinoline

→

title compound

収率 69.4%

7-Chloro-6-fluoro-2-hydroxymethylquinoline

収率 69.4%

溶媒

methanol

反応条件

後処理

1. 1
   その他obtained in Reference example 2
2. 2
   その他After the solvent was removed
3. 3
   抽出the residue was extracted with ice water-methylene chloride
4. 4
   洗浄the organic layer was washed with water
5. 5
   乾燥dried over anhydrous sodium sulfate
6. 6
   その他After the solvent was removed

実験手順

3 g of sodium boron hydride was added to 11.19 g of 7-chloro-6-fluoro-2-formylquinoline obtained in Reference example 2 suspended in 250 ml of methanol and the mixture was stirred at room temperature for 1 hour. After the solvent was removed, the residue was extracted with ice water-methylene chloride and the organic layer was washed with water and dried over anhydrous sodium sulfate. After the solvent was removed, the residue was applied to silica gel column chromatography to obtain 7.84 g of the title compound.

出典