反応 #319982

反応方程式

3α-Acetoxy-5α-pregnan-20-one

N-bromosuccinimide

benzoyl peroxide

→

3α-Acetoxy-17α-bromo-5α-pregnan-20-one

溶媒

carbon tetrachloride

反応条件

後処理

1. 1
   温度The reaction mixture was cooled
2. 2
   ろ過filtered
3. 3
   洗浄washed with sodium bisulfite, water, and brine
4. 4
   濃縮concentrated
5. 5
   その他to give a crude reddish oil

実験手順

3α-Acetoxy-5α-pregnan-20-one (3 g, 360.5 g/m, 8.3 mmol), N-bromosuccinimide (2.7 g, 178 g/m, 15 mmol), and benzoyl peroxide (200 mg, 242 g/m, 0.83 mmol) dissolved in 50 ml of carbon tetrachloride were refluxed overnight (ca. 16h). The reaction mixture was cooled, filtered, and washed with sodium bisulfite, water, and brine, and then concentrated to give a crude reddish oil.

出典