反応 #319496

反応方程式

2-chloroethylamine hydrochloride

3-chlorophenol

sodium hydride

3-chlorophenol

→

title compound

2-[3-Chlorophenoxy]ethylamine

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   濃縮Concentrate the reaction mixture
2. 2
   その他partition between 200 mL of methylene chloride and 50 mL water
3. 3
   乾燥Dry the organic layer over Na2SO4
4. 4
   濃縮concentrate in vacuo

実験手順

Add 5.0 g (38.9 mmol) of 3-chlorophenol to a 0° C. suspension of 3.42 g (85.6 mmol, 2.2 eq., 60% by wt. in mineral oil) of sodium hydride in 100 mL of dry tetrahydrofuran. Once the 3-chlorophenol is dissolved add 9.93 g (85.6 mmol, 2.2 eq.) of 2-chloroethylamine hydrochloride and stir at room temperature for 17 hr. Concentrate the reaction mixture and partition between 200 mL of methylene chloride and 50 mL water. Dry the organic layer over Na2SO4 and concentrate in vacuo to obtain the title compound.

出典