反応 #319080

反応方程式

6-trifluoromethyl- quinazolin-4-(3H)-one

methyl trans-2-(3-bromo-2-oxoproyl)3-methoxypiperidine-1-carboxylate

→

title compound

収率 24.0%

Methyl trans-2-[3-(6-Trifluoromethylquinazolin-4-(3H)-on-3-yl)-2-oxopropyl]-3-methoxypiperidine-1-carboxylate

収率 24.0%

反応条件

実験手順

By the method of Example 4, 6-trifluoromethyl- quinazolin-4-(3H)-one and methyl trans-2-(3-bromo-2-oxoproyl)3-methoxypiperidine-1-carboxylate were converted into the title compound in 24% yield; m.p. 137°-140° C. 1H-NMR(CDCl3) 1.4-1.9 (m, 4H), 2.9 (d, 2H), 3.3 (s, 3H), 3.5-3.9 (m,4H), 3.7 (s, 3H), 5.2 (s, 2H), 7.7-8.7 (m,4H).

出典