反応 #318466

反応方程式

sodium butyl 2-hydroxy-3chloropropyl phosphate

sodium hydroxide ethanol

→

sodium butyl glycidyl phosphate

収率 100.0%

溶媒

ethanol

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他to obtain a uniform mixture
3. 3
   温度Thereafter, the reaction system was cooled down to room temperature, to which
4. 4
   その他The resultant NaCl precipitate was removed by filtration
5. 5
   workup.DISTILLATIONthe ethanol was distilled off under reduced pressure

実験手順

50 g (0.19 mol) of sodium butyl 2-hydroxy-3chloropropyl phosphate was charged into a reactor, to which 1000 ml of ethanol was added, followed by agitation and heating to 70° C. to obtain a uniform mixture. Thereafter, the reaction system was cooled down to room temperature, to which was gradually added 88.6 g (0.19 mol) of a 0.0021 mol/g sodium hydroxide ethanol solution, followed by agitation for 3 hours while keeping the temperature. The HPLC analysis revealed the disappearance of a peak of the starting material with a peak for the resultant new product appearing. The resultant NaCl precipitate was removed by filtration and the ethanol was distilled off under reduced pressure to obtain 43 g (yield: 100%) of sodium butyl glycidyl phosphate.

出典