反応 #318321

反応方程式

2-acetylamino thiazole

2-(1-propenyl)-8-trifluoromethyl-4H-3,1-benzoxazin-4-one

crotonyl chloride

2-amino-trifluoromethyl benzoic acid

→

β-oxo-2-[(1-oxo-2-butenyl)-amino]-N-(2-thiazolyl)-3-trifluoromethyl-benzene-proponamide

収率 70.6%

反応条件

後処理

1. 1
   その他prepared by Step A of Example 12 of European Pat

実験手順

Using the procedure of Step A of Example 1, 19.44 g of 2-acetylamino thiazole and 17.3 g of 2-(1-propenyl)-8-trifluoromethyl-4H-3,1-benzoxazin-4-one [prepared by Step A of Example 12 of European Pat. No. 40,573 from crotonyl chloride and 2-amino-trifluoromethyl benzoic acid] were reacted to obtain 19.03 g of β-oxo-2-[(1-oxo-2-butenyl)-amino]-N-(2-thiazolyl)-3-trifluoromethyl-benzene-proponamide melting at 206°-208° C.

出典