反応 #317961

反応方程式

Triphenyl phosphine

diethyl azodicarboxylate

2-hydroxypyridine

methyl 4-hydroxymethylbenzenecarboxylate

→

compound

収率 22.3%

Methyl 4-(pyridin-2-yloxymethyl)benzenecarboxylate

収率 22.3%

溶媒

THF

THF

反応条件

後処理

1. 1
   濃縮The reaction solution was concentrated under reduced pressure
2. 2
   その他the resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=9/1 to 2/3 to ethyl acetate alone)

実験手順

Triphenyl phosphine (614 mg) and a THF solution (1 mL) of diethyl azodicarboxylate (408 mg) were added in that order to a THF solution (20 mL) of 2-hydroxypyridine (149 mg) and methyl 4-hydroxymethylbenzenecarboxylate (260 mg), and stirred overnight at room temperature. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=9/1 to 2/3 to ethyl acetate alone) to obtain the entitled compound (85 mg).

出典